Synthesis of 1′, 2′-Dihydrospiro[cyclohexane-1, 4′(3′<i>H</i>)-isoquinoline]-6′-ol Derivatives by the Bischler-Napieralski Reaction
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منابع مشابه
The cyclization reaction of ortho-ethynylbenzaldehyde derivatives into isoquinoline derivatives.
In order to elucidate the reaction mechanism of the cyclization between an ethynyl group and an imino group at the ortho-position on an aromatic ring to afford isoquinolines, reaction of 2-ethynylbenzaldehydes under various conditions was examined. It is concluded that reaction proceeds via an ionic process and the isoquinoline 4-hydrogen atom derives from the solvent. In addition, it was found...
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Oxazoles are interesting from both a pharmacological and a chemical point of view. For example, they are known to interact with various proteins such as sodium-dependent excitatory amino acid transporters [1] or DNA repair protein OG-alkylguanine DNAalkyl-transferase [2], and furthermore, they display bacteriostatic [3] and antiinflammatory activity [4]. Additionally, oxazoles provide useful en...
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Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...
متن کاملDesign, Synthesis and Cytotoxicity Evaluation of New 2-Aryl-5,6-Dihydropyrrolo[2, 1-a]Isoquinoline Derivatives as Topoisomerase Inhibitors
Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1963
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.83.11_1026